PICS Colloquium with Omar Valsson: From Stability to Dissociation: Elucidating Unbinding Kinetics of Protein-Protein Complexes via Atomistic Simulations
Abstract: Protein-protein interactions (PPI) are ubiquitous in biological processes. Their study has significant implications for drug discovery as PPIs are important pharmacological targets for small molecules and important in various therapeutic modalities, such as targeted protein degradation and antibodies. Therefore, understanding the stability and dissociation of protein-protein complexes is of great fundamental and practical interest. […]